Talk show se poprvé vysílala 8. září 1986 a dosud se objevila v televizním vysílání 145 zemí. Jenom v USA ji týdně sleduje kolem 42 milionů lidí.
Celebrity mají k Winfrey, která je navíc populárnější než řada z nich, důvěru a často jí svěřují exkluzivní informace. Herec Tom Cruise v jejím pořadu například v roce 2005 velmi nadšeným způsobem, který byl později často parodován, mluvil o své lásce k mnohem mladší herečce Katie Holmesové a poskakoval při tom na gauči. Zpěvák Michael Jackson zase v její talk show v roce 1993 odhalil, že trpí nemocí, která způsobuje blednutí jeho pokožky. Velkou publicitu získal její rozhovor s bývalou kandidátkou na viceprezidentku Spojených států Sarah Palinovou, jež v The Oprah Winfrey Show představila své paměti. V roce 2007 pak Winfrey v dalším slavném okamžiku vysílání své show se slovy "Dostáváš auto! Dostáváš auto! I ty dostáváš auto! Každý dostává auto!" věnovala všem 276 divákům ve studiu auta. Vozy v hodnotě sedmi milionů dolarů nicméně dostala darem od automobilky General Motors.
Po 25 letech však Oprah Winfrey show končí. Naposledy se pořad vysílá 9. září 2011.
Účinkují: Oprah Winfrey, Kate Walsh, Marlee Matlin, Brad Garrett, Ricardo Chavira, James Denton, Lisa Ling, Alicia Keys, Raven-Symoné, .....Thandiwe Newton, Bryce Dallas Howard, Yolanda Adams, Jaden Smith, Jennifer Hudson, Beyoncé, Tami Roman, Keke Palmer, Jim Sturgess, Justin Guarini, Gisele Bündchen, Nicole Richie, Dennis Miller, Al Gore, Lauren Shiohama, Donald Trump, Mel Gibson, Charles Barkley, Tina Turner, Christina Aguilera, Sylvester Stallone, Keshia Knight Pulliam, Brad Pitt, Robert Downey Jr., Tyra Banks, Eddie Murphy, Joaquin Phoenix, Blair Underwood, George Clooney, Reese Witherspoon, Sharon Stone, Tom Cruise, Jamie-Lynn Sigler, Johnny Depp, Mariah Carey, Jamie Foxx, John Travolta, Jim Carrey, Jennifer Aniston, Julia Roberts, Chris Rock, Salma Hayek, Will Smith, Dolly Parton, Halle Berry, Felicity Huffman, Jon Stewart, Hilary Swank, Bill Cosby, Sidney Poitier, Tyler Perry, Nicole Kidman, Bernie Mac, Mary J. Blige, Mike Myers, Kelly Preston, Gwyneth Paltrow, Priscilla Presley, Liza Minnelli, Cyndi Lauper, Keenen Ivory Wayans, Madonna, Lisa Kudrow, Sandra Bullock, Kim Cattrall, Denzel Washington, Susan Sarandon, Jennifer Lopez, Dakota Fanning, Michael Douglas, Drew Barrymore, Ashley Olsen, Mary-Kate Olsen, Kirstie Alley, Teri Hatcher, Eva Longoria, Stevie Wonder, Queen Latifah, Terrence Howard, Matthew McConaughey, Brooke Shields, Dan Aykroyd, Clint Black, Lisa Hartman, Barbra Streisand, Diahann Carroll, Natalie Portman, Kate Capshaw, Meg Ryan, Cher, Bono, Julianne Moore, Ashley Judd, Jamie Kennedy, Courteney Cox, Billy Crystal, Matt LeBlanc, Tobey Maguire, Matthew Perry, David Schwimmer, Kirk Douglas, Kristin Davis, Cynthia Nixon, Sarah Jessica Parker, Mario Lopez, Antonio Banderas, Sean 'Diddy' Combs, Marcia Cross, Leonardo DiCaprio, Hugh Grant, Melanie Griffith, Tom Hanks, Jude Law, Jada Pinkett Smith, Kelly Rowland, Adam Sandler, Jerry Seinfeld, Nicollette Sheridan, Jessica Simpson, Steven Spielberg, Michelle Williams, Kate Winslet, Renée Zellweger, Cameron Diaz, Simon Cowell, Geena Davis, Matt Dillon, Will Ferrell, Debra Messing, Charlize Theron, Michael Jordan, Usher, Ray Romano, Robin Williams, William H. Macy, Forest Whitaker, Heath Ledger, Ellen Pompeo, Isaiah Washington, Jamie Oliver, Ice-T, Michael Michele, Sigourney Weaver, Rachel Weisz, Martin Luther, Miley Cyrus, Barack Obama, Vince Vaughn, Nikki Blonsky, Brenda Song, Josh Groban, Tempestt Bledsoe, Aretha Franklin, Penn Jillette, Susan Boyle, John Legend, Aishwarya Rai Bachchan, Betty White, Prince, Sage Stallone, Jaclyn Smith, Céline Dion, Kathy Griffin, Lara Flynn Boyle, Adam Carolla, Kari Wuhrer, Jennifer Crystal Foley, Riley Keough, Marion Ross, Amy Ryan, Danny Glover, Paul Anka, Nate Parker, Denzel Whitaker, Gloria Estefan, Alexandra Wentworth, Roger Ebert, Naomi Judd, Mo'Nique, Lady Gaga, Harold Ramis, Neil Diamond, Kelly Ripa, Carrie Underwood, Mark Consuelos, Curtis Stone, Steve Burton, Ty Pennington, Taylor Lautner, Kristen Stewart, Robert Pattinson, Tom Ford, Tyler James Williams, Criss Angel, Geoffrey Fletcher, David Blaine, Shonda Rhimes, Cody Kasch, Jamie Lynn Spears, Kenny Rogers, James Taylor, Kody Brown, Annette Funicello, David Arquette, J. K. Rowling, Daniel Radcliffe, Eric Stonestreet, Maurice Gibb, Angela Cartwright, Susan Saint James, Jackée Harry, Joan Jett, Stephenie Meyer, Anne Rice, Amy Sedaris, Dustin Lance Black, Peter Frampton, Jonathan Franzen, Rosalind Wiseman, Jake Zyrus, Todd Bridges, Mackenzie Phillips, Anya Monzikova, Dianna Agron, Lea Michele, Kelly Monaco, Genie Francis, Dionne Warwick, Sean Hayes, Jeanne Cooper, Deidre Hall, Nick Benedict, Shirley Jones, Garrett Morris, Daisy Fuentes, Nick Carter, Nate Berkus, Derek Hough, Michelle Obama, Jackie Evancho, Stevie Nicks, Michael Nader, Fantasia Barrino, Charles Frank, Tony Bennett, Jesse Jackson, Hillary Clinton, Ryan Seacrest, Georgia Engel, Rick Hearst, Naomi Campbell, Tom Bergeron, Erin Andrews, Steven Tyler, Ana Gasteyer, Aimee Mullins, Leona Lewis, Lionel Richie, David Cassidy, Mark Zuckerberg, Mark Burnett, Jeff Probst, Ashley Edner, Bruno Tonioli, Steven W. Bailey, Howard Lyman, David Bryan, Freddie Highmore, Jerry Mathers, Chris Evert, Martina Navrátilová, Sabrina Le Beauf, Geraldo Rivera, Kate Gosselin, Shawn Johnson, Donald Trump Jr., Eric Trump, Melania Trump, Wynonna Judd, Rachael Ray, Tim Gunn, Martha Stewart, Johnny Weir, Cesar Millan, Bill Gates, Bonnie Raitt, Patti LaBelle, Chris Christie, Emma Watson, Rupert Grint, Michael E. Knight, Lisa Marie Presley, Michael Lockwood, LeBron James, CeeLo Green, Willow Smith, Liberace, Sarah Palin, Lorne Michaels, Kandis Mak, L.A. Reid, Mehmet Oz, Jason Jones, Talia Toms, Donny Osmond, Andrea Bocelli, Tico Torres, Richie Sambora, Chaz Bono, Sheryl Berkoff, Isaiah Mustafa, Diane Sawyer, Viveca Paulin, Karen Ceesay, Cory Monteith, Kimberly Caldwell, Anderson Cooper, Whitney Houston, Florence Henderson, Liviu Tipurita, Jay DeMarcus, Marlon Wayans, Shawn Wayans, Mark Moses, Dante Brown, Lindsay Crystal, James Blunt, Henry Louis Gates, Ralph Lauren, Tom Papa, Tavia Schwartz, Tony Gonzalez, Darnell Williams, John O'Hurley, Donna Hanover, Frances Callier, Carson Kressley, Kimberly Reed, Mark Salling, Joy Behar, Paris Jackson, Kym Karath, Isaac Mizrahi, Donna Summer, Maria Shriver, Marissa Jaret Winokur, Robert Clarence Irwin, Chynna Phillips, Montel Williams, Bobbi Kristina Brown, Andrew Lauren, Sarah Ferguson, Sam Harris, Mike Kimmel, Marie Osmond, Peggy Rowe, Roberta Flack, Sharon Brathwaite, Drew Pinsky, Michael Kors, Phil Rosenthal, Kathy Garver, Davy Jones, Peter Noone, Tony Parker, Karina Smirnoff, Christie Brinkley, T.D. Jakes, Seal, D. Danny Warhol, Patrick Page, Ted Koppel, Diane von Fürstenberg, Greg Louganis, Faith Hill, Dan Rather, Kirk Franklin, Stella Parton, Chaz Ebert, Merrill Osmond, Jay Osmond, Alan Osmond, Jackie Jackson, A.J. McLean, Brian Littrell, Howie Dorough, Stephanie Seymour, Tara Conner, Nyima Funk, Kenneth 'Babyface' Edmonds, Cheryl 'Salt' James, Sandra 'Pepa' Denton, Deidra 'Spinderella' Roper, Christian Siriano, Cristina Ferrare, Charlotte Laws, Tonya Harding, Kristi Yamaguchi, Cormac McCarthy, Charles Grant, Christy Turlington, Dan Buettner, Carrie Ann Inaba, Mayte Garcia
Archivní záběry: Carmen Electra
Režie: Joseph C. Terry
Hudba: Matthew Richard Harris, Yoshi Miyamoto, Stuart Roslyn, Armen Chakmakian, Ed Smart
Kamera: Daniel Pfisterer, Keith Walker
Střih: Larry Sexton
Kostýmy a make-up: Robert White
Zvuk: Nick Emond
