V pořadí již čtvrtá verze Late Night show, kterou po Davidu Lettermanovi, Conanu O'Brianovi a Jimmym Fallonovi přebírá Seth Meyers, dlouholetý hlavní scénárista pořadu Saturday Night Live a moderátor jeho zprávařské vložky Weekend Update. Late Night with Seth Meyers stejně jako předchozí verze pořadu začíná monologem a poté se soustředí na rozhovory s (nejen) americkými hvězdami. Setha doplňuje jeho bývalý kolega z SNL Fred Armisen, který zde slouží jako bandleader The 8G bandu. Každý den od půl jedné na NBC hned pod The Tonight Show starring Jimmy Fallon.
Účinkují: Seth Meyers, Fred Armisen, Michelle Wolf, Amy Poehler, Kanye West, Kelly Ripa, Lena Dunham, Anthony Mackie, Ian McKellen, .....Patrick Stewart, Sophia Bush, John Lutz, Robyn Doolittle, Naomi Campbell, Ralph Fiennes, Allison Williams, Mike Birbiglia, Ice-T, Nick Kroll, Rick Ross, Kenan Thompson, Lil' Jon, Andy Samberg, Busy Philipps, Ilana Glazer, Abbi Jacobson, Rachel Maddow, Norman Reedus, Tilda Swinton, Carrie Brownstein, Christian Slater, Alessandra Ambrosio, Iggy Azalea, Jason Sudeikis, Kathryn Hahn, Wendy Williams, Lena Headey, Greg Kinnear, Shailene Woodley, Zosia Mamet, John Leguizamo, Kyle MacLachlan, Kathie Lee Gifford, Arianna Huffington, Taran Killam, Cristin Milioti, Timothy Olyphant, Kevin Bacon, Katherine Schwarzenegger, Anna Kendrick, Nick Cannon, Jennifer Connelly, Bob Costas, Steve Coogan, Whoopi Goldberg, Judd Apatow, Jeremy Piven, Colin Hanks, Kristen Wiig, Denis Leary, Edie Falco, Marlon Wayans, Sofía Vergara, Natalie Dormer, Cameron Diaz, Leslie Mann, Daniel Radcliffe, Jessica St. Clair, Lennon Parham, Matt Lauer, Matt Walsh, Lucy Liu, Rose Byrne, Kiefer Sutherland, Richard Ayoade, Chris Kattan, Mindy Kaling, Jenna Elfman, Elliot Page, Lewis Black, Sarah Jessica Parker, Jon Hamm, Larry King, Chris O'Dowd, Emma Roberts, Will Forte, Matthew Rhys, Tina Fey, Eddie Izzard, Maya Rudolph, Lake Bell, James McAvoy, Wendi McLendon-Covey, Kumail Nanjiani, Jennifer Lawrence, Alan Cumming, Hugh Jackman, Kevin Nealon, Megan Mullally, Nick Offerman, Gilbert Gottfried, Dennis Miller, Anna Chlumsky, Demi Lovato, Martin Short, Jonah Hill, Laura Dern, Steve Buscemi, Aidy Bryant, John Oliver, Natasha Lyonne, Chris Rock, Gerard Butler, Tony Shalhoub, Robert Pattinson, America Ferrera, David Wain, Piper Perabo, Wanda Sykes, Neil deGrasse Tyson, Mike Myers, Whitney Cummings, Jenny Slate, Paul Haggis, Josh Meyers, Brad Paisley, Vanessa Bayer, Taye Diggs, Andy Serkis, Keri Russell, Kate McKinnon, Anna Paquin, Marc Maron, Regis Philbin, John Henson, Julie Bowen, Brett Ratner, Zach Braff, Kate Hudson, Ricky Gervais, Hank Azaria, Mary Lynn Rajskub, Brendan Gleeson, Penn Jillette, Teller, Maggie Gyllenhaal, Lee Pace, Chris Pratt, Ethan Hawke, Joan Rivers, Clive Owen, Sarah Paulson, Michael Fassbender, Allison Tolman, Dane DeHaan, Mickey Rourke, Matthew Weiner, Taylor Swift, Boy George, Derek Waters, Amy Sedaris, Stephen Colbert, Gwen Stefani, Heidi Klum, Kieran Culkin, Luke Wilson, Max Greenfield, Billy Eichner, Jeff Goldblum, Jeffrey Kluger, Connie Britton, Ben McKenzie, Harry Connick, Jr., Josh Charles, Nick Jonas, Bill Hader, Craig Ferguson, Octavia Spencer, James Ellroy, Adam Pally, Julianna Margulies, Viggo Mortensen, Jennifer Hudson, Patrick Wilson, Stephen King, Emily VanCamp, Rosamund Pike, Michael Che, Dan Bakkedahl, Ella Henderson, Nathan Lane, 'Weird Al' Yankovic, Garry Marshall, Neil Patrick Harris, Rita Wilson, Sarah Silverman, John Mulaney, James Spader, Rachel Dratch, Charli XCX, Jessie Ware, Hozier, Andy Roddick, Matthew Broderick, Zachary Quinto, Robert Downey Jr., Emmy Rossum, Ike Barinholtz, Leslie Jones, Thomas Middleditch, Al Roker, Hoda Kotb, Chrissy Teigen, Martha Stewart, Johnny Weir, Coco Austin, Erin Foster, Dan Patrick, Laverne Cox, Tim Robinson, Michael Patrick O'Brien, Brooks Wheelan, Colin Quinn, M.I.A., Michael Strahan, Mehmet Oz, Bob Mould, Tig Notaro, Bill O'Reilly, Michael Lewis, Kit Harington, Megyn Kelly, Anna Wintour, Bernie Sanders, Hannibal Buress, Holly Holm, Anderson Cooper, Father John Misty, French Montana, Angela Bassett, Zac Posen, Chad Smith, Chris Baio, Christine and the Queens, Krysta Rodriguez, Kate Pierson, Ali Wong, Jess Glynne, Helen Mirren, Adam Driver, Chris Stapleton, Corey Glover, Bebe Rexha, Misty Copeland, Jillian Rose Banks, Big Sean, Michael Schur, Scott Aukerman, Roy Wood Jr., Alex Wyse, Charlie Rose, Margo Price, Glenn Kotche, Lucius, Robert Kazinsky, Anthony Bourdain, Shiri Appleby, Miranda Lambert, Joe Mande, Patrick J. Carney, Bryan Safi, Nathan Fielder, Michael Voltaggio, Jamie XX, Maren Morris, Sturgill Simpson, Alessia Cara, Simon Rich, Jordan Klepper, Venzella Joy, DJ Khaled, Ray Luzier, A$AP Ferg, Kid Ink, G-Eazy, J. Mascis, Beanie Feldstein, Ronan Farrow, Troye Sivan, Phoebe Robinson, Joy Behar, Jenni Konner, Bryan Fogel, Fortune Feimster, Amanda Cowper, Sean Grandillo, Jack Antonoff, Emily Skeggs, Eugene Mirman, Post Malone, Sebastian Maniscalco, Hannah Gadsby, Cody Lindquist, Amanda Seales, Carson Daly, Marina, Austin P. McKenzie, Tori Kelly, Thomas Lang, Rudy Giuliani, Amber Rose, Buzz Bissinger, Laura Dreyfuss, Sandra Mae Frank, Alex Guarnaschelli, LP, Calum Scott, Hari Nef, Kellyanne Conway, Elly Jackson, Soledad O'Brien, Kimbra, Aaron Dalla Villa, Roberta Colindrez, Aubrey Plaza, Jeff Koons, Alexandria Ocasio-Cortez, Elizabeth Olsen, Meghan McCain, Daniel Kongos, Dylan Kongos, Jesse Kongos, John Kongos, Robin Thede, Kacey Musgraves, Lindsey Vonn, James III, Ben Warheit, Daniel Durant, Astrid S, Jeremy O. Harris, Yungblud, Eleanor Friedberger, Daniel David Stewart, Doja Cat, Aaron D. Spears, Will Butler, Rileigh McDonald, Jake Tapper, Sam Fender, Elaine Bradley, Jessie Reyez, Ezra Edelman, Kelsea Ballerini, AJ Kane, Megan Rapinoe, Jon Spurney, Austin Brown, D'Arcy Carden, Luke Bryan, Joe Biden, Tarik Davis, Travis Kelce, Lauren Daigle, Mohsin Hamid, Tony Parker, John Tempesta, Sarah Jones, Pete Buttigieg, Ta-Nehisi Coates, Chioke Nassor, Guy Fieri, Patrick Radden Keefe, Andrew Law, Julien Baker, Travis Scott, Brian Michael Bendis, Christina Tosi, Tom Odell, Patricia Williams, Diane von Fürstenberg, Kurt Braunohler, Jon Wurster, Joyelle Johnson, Sorika Wolf, Antonio Brown, Clayton English, Martin Shkreli, Blake Griffin, Alan Sepinwall, Josie Duffy Rice, Ingrid Andress, Norah O'Donnell, Catherine Cohen, Latto, Armie Hammer, girl in red, Kamala Harris, Tate McRae, Keith Morrison, Lucy Dacus, Conan Gray, Katrina Lenk, Alex Boniello, Betty Who, Cazzie David, Anthony Fauci, José Andrés, Andy Cohen, Christian Siriano, Treshelle Edmond, Rich Eisen, Kenny Smith, Chris DiStefano, Anthony Doerr, Alex Ross, Ilan Rubin, Ben Schneider, Peter Grosz, Abe Cunningham, Seth Reiss, Shane Smith, Finesse Mitchell, Chuck Todd, Birdy, Sam Esmail, Sam Nelson Harris, Casey Harris, Adam Levin, George Stephanopoulos, Michael Rezendes, Roger Bennett, Wright Thompson, Kaitlan Collins, Pete Rose, Beth Malone, Chuck Klosterman, Josh Freese, Patrisse Cullors, Kwame Onwuachi, Matty Matheson, Carmen Christopher, James Blake, Matt Fraction, Joshua Caro, Joe Pera, DaniLeigh, Jaquel Spivey, Amor Towles
Archivní záběry: Killer Mike, Mike Huckabee, Rodrigo Duterte, Mick Fanning, Warren Buffett, Rob Gronkowski, Joaquín Guzmán Loera, Sean Hannity, Mike Pence, .....France Gall, Howard Stern
Scénář: John Lutz, Seth Meyers, Michelle Wolf, Colin Jost, Erik Kenward, Mike Karnell, Aparna Nancherla, Ben Warheit, Chioke Nassor, .....Andrew Law, Peter Grosz, Seth Reiss
Hudba: Jeremy Sweet
